In a Brazilian registry of 1,154 hypertensive patients, resistant hypertension prevalence was 8.5% and was independently associated with disability (OR 6.08) and low education (OR 1.64).
Cross-Sectional (n=1,154)
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In a Brazilian registry, resistant hypertension was present in 8.5% of patients and was independently associated with social factors such as low education and disability.
Odds Ratio: 6.08 (95% CI 1.47–25.2)
Objective: Identification of true resistant hypertension(RH) is difficult in the real world. We aim to analyze baseline data from participants included in Brazil in iCaReMe study, an international, prospective, multicenter registry, to evaluate the independent variables associated with RH and the association between RH and cardiac, renal, and metabolic complications. Design and method: Patients with a history of hypertension, diabetes, chronic kidney disease(CKD), or heart failure(HF) were eligible for inclusion in the registry. Patients were treated according to each center's local standards of care. RH was defined as the absence of achieving BP goal with 3 or more antihypertensive drugs(at least one diuretic) or achieving this goal with 4 or more classes(< 130 x 80 mmHg in patients with diabetes, CKD, or CV disease, and < 140 x 90 mmHg in patients without these conditions). The variables were selected from the baseline data. A sensitivity analysis was done considering the targets and the patients with RH at baseline. Multivariate logistic regression models were performed to adjust for covariates. Results: Data from 1154 patients with hypertension were evaluated. The mean age was 64.2±12 years, and 43% were male. We identified 8.5%(n=99) of patients with RH, who had significantly(p<0.05) higher BMI(30.1±6 vs. 28.5±5 kg/m2), greater use of antihypertensive classes(4.6±0.8 vs. 1.8±1), higher percentage of black individuals(24.6 vs. 10.2%), lower schooling(< 6 years – 59.7 vs. 38.7%; higher -10.4 vs. 27.2%), and higher proportion of unemployed individuals(11.4 vs. 3.6%) when compared to individuals with controlled hypertension. In addition, patients with RH had more chronic kidney disease(CKD)(18.9 vs. 8.5%) and more strokes(17.4 vs. 9%). Logistic regression analysis showed that the only independent factors associated with RH were social factors: disability(OR 6.08, 95% CI 1.47-25.2) and not having higher education level(OR 1.64, 95% CI 1.11-1.97) Conclusions: In a real-world registry in Brazil of patients with hypertension and comorbidities, the prevalence of RH was 8.5%. Black and obese patients were more likely to present RH, and the independently associated factors were low education and disability. Patients with RH had a higher prevalence of renal and cerebrovascular complications.
bortolotto et al. (Fri,) conducted a cross-sectional in Hypertension (n=1,154). Disability and low education vs. Absence of disability and higher education was evaluated on Resistant hypertension (OR 6.08, 95% CI 1.47-25.2). In a Brazilian registry of 1,154 hypertensive patients, resistant hypertension prevalence was 8.5% and was independently associated with disability (OR 6.08) and low education (OR 1.64).