ABSTRACT Skin cancer has become a major health concern with increasing incidence and mortality rates worldwide. In recent years, lipid‐based nanoparticles have emerged as novel therapeutic platforms for skin cancer therapy, offering enhanced biocompatibility, drug encapsulation capabilities, and targeted drug delivery to the tumor site. Clinical findings have suggested the ability of lipid nanoparticles to overcome skin and tumor microenvironment barriers, reduce systemic toxicity, and enhance drug accumulation at tumor sites. The objective of this review is to address and inspire future research and clinical adoption of lipid‐based nanotechnology, underscoring their potential to revolutionize precision skin cancer management through safer, more effective, and patient‐tailored interventions in the future. Various research and review articles were referred and compiled based on the literature from different electronic databases, including Google Scholar, ResearchGate, PubMed, Scopus, Web of Science, Embase, Elsevier, and Springer. This review provides detailed recent developments in formulation strategies, novel stimuli‐responsive and multifunctional systems, and surface modifications to improve specificity to tumor cells and their therapeutic outcomes. Lipid nanoparticles can revolutionize the future of skin cancer therapy and diagnosis. As clinical trials progress, more effective and personalized therapies are expected to emerge.
Negi et al. (Mon,) studied this question.