A home-based intervention of DASH diet and exercise did not significantly reduce the primary endpoint of office systolic blood pressure compared to usual advice (-3.6 mmHg vs 2.0 mmHg, p=0.347).
RCT (n=85)
Open-label
permuted 6 block randomizations
No
Does a home-based lifestyle modification intervention combining the DASH diet and exercise reduce blood pressure in patients with prehypertension or mild hypertension?
A home-based lifestyle modification program combining the DASH diet and exercise significantly reduced daytime ambulatory systolic blood pressure compared to usual care in patients with prehypertension or mild hypertension.
Tasa de eventos absoluta: -3.6% vs 2%
valor p: p=0.347
BACKGROUND AND OBJECTIVES: Supervised lifestyle interventions, including dietary and exercise programs, may be infeasible to implement in real-world settings. Therefore, this study aimed to evaluate the effectiveness of a home-based lifestyle modification intervention on blood pressure (BP) management. METHODS: Eighty-five patients aged over 20 years and diagnosed with prehypertension or mild hypertension were randomly assigned to an advice-only comparison group (C group, n=28), a Dietary Approaches to Stop Hypertension (DASH) diet education group (D group, n=30), or a DASH and home-based exercise group (D+Ex group, n=27). The intervention lasted for 8 weeks. The primary outcome was the difference in office systolic blood pressure (SBP) before and after the study period (Trial registry at ClinicalTrials.gov, NCT01637909). RESULTS: Seventy-two participants (87.8%) completed the trial. The degree of change in office SBP did not significantly differ among the intervention groups; however, the D+Ex group demonstrated a tendency toward decreased SBP. Upon analysis of 24-hour ambulatory BP measurements, daytime ambulatory SBP was significantly lower in the D+Ex group (134 mmHg; 95% confidence interval CI, 131 to 137; p=0.011) than in the C group (139.5 mmHg; 95% CI, 130.9 to 137), and daytime ambulatory SBP was significantly decreased in the D+Ex group (-5.2 mmHg; 95% CI, -8.3 to -2.1; p=0.011) compared to the C group (0.4 mmHg, 95% CI, -2.5 to 3.3). CONCLUSIONS: In conclusion, lifestyle modification emphasizing both diet and exercise was effective for lowering BP and should be favored over diet-only modifications.
Lee et al. (Mon,) conducted a rct in Prehypertension and mild hypertension (n=85). DASH diet alone or with home-based exercise vs. Usual advice was evaluated on Difference in office systolic blood pressure (SBP) before and after the 8-week study period (p=0.347). A home-based intervention of DASH diet and exercise did not significantly reduce the primary endpoint of office systolic blood pressure compared to usual advice (-3.6 mmHg vs 2.0 mmHg, p=0.347).