Early Atypical Manifestations of Leukemia

Article1 October 1954EARLY ATYPICAL MANIFESTATIONS OF LEUKEMIAGORDON C. MEACHAM, M.D., AUSTIN S. WEISBERGER, M.D.GORDON C. MEACHAM, M.D.Search for more papers by this author, AUSTIN S. WEISBERGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-4-780 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe diagnosis of leukemia by clinical and laboratory studies is usually not difficult. Occasionally, however, the initial manifestations of the leukemic process may be atypical and precede the onset of clinically recognizable leukemia by several years. The abnormal hematologic findings are not specific and consist of various combinations of anemia, leukopenia, neutropenia and thrombocytopenia, with a hyperactive marrow. The spleen is usually not palpable or only slightly enlarged. Initially these cases often resemble the syndrome usually designated as "primary" splenic panhematopenia.1, 2The following report deals with 10 patients manifesting the above findings who were studied during the past five...Bibliography1. DoanWright CACS: Primary congenital and secondary acquired splenic panhematopenia, Blood 1: 10, 1946. CrossrefMedlineGoogle Scholar2. Doan CA: Hypersplenism, Bull. New York Acad. Med. 25: 625, 1949. MedlineGoogle Scholar3. BlockJacobsonBethard MLOWF: Preleukemic acute human leukemia, J. A. M. A. 152: 1018, 1953. CrossrefMedlineGoogle Scholar4. WelchDameshek CSW: Splenectomy in blood dyscrasias, New England J. Med. 242: 601, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GORDON C. MEACHAM, M.D.; AUSTIN S. WEISBERGER, M.D.*Received for publication March 29, 1954.From the Department of Medicine, Western Reserve University School of Medicine, Cleveland, Ohio.This study was aided by a grant from the Price-McKinney Fund, University Hospitals of Cleveland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Preleukemic Syndrome: Clinical and Laboratory Features, Natural Course, and ManagementErythroleukemia and Myelodysplastic Syndromes: An Historical Appraisal and a Personal ViewThe Preleukemic Syndrome (Hematopoietic Dysplasia)The preleukemic syndrome (hematopoietic dysplasia)The concept of preleukemia: Clinical and laboratory studiesChronic monocytic leukemia in adultsGlucocorticoid Therapy in the Preleukemic Syndrome (Hemopoietic Dysplasia) Identification of Responsive Patients Using In-Vitro TechniquesGROVER C. BAGBY Jr., M.D., JOHN D. GABOUREL, Ph.D., JAMES W. LINMAN, M.D.The preleukemic syndromeAcute (“malignant”) myelosclerosisConventional Morphological Examination of Blood and Bone Marrow Cells in the Diagnosis of Preleukemic SyndromesPreleukaemia and Reticulocytosis: A Case Report with in Vitro Evidence for Abnormal Reticulocyte MaturationDie PräleukämieThe Dilemma of HypersplenismSubacute myelomonocytic leukemiaHereditary splenomegaly with hypersplenismTWO AUTOPSY CASES OF ATYPICAL MYELOPROLIFERATIVE DISORDER WITH GROUP C MONOSOMY OCCURRING IN SIBLINGSPreleukemiaCoagulation Studies in Patients with Acute Infectious HepatitisAcute childhood leukemia presenting as aplastic anemia: The response to corticosteroidsChronic erythromonocytic leukemiaChronic monocytic dyscrasia culminating in acute leukemiaLeukosen und RetikulosenThe pre-leukaemic stateEditorialsSmoldering Acute LeukemiaIneffective erythropoiesisHypersplenism Due to InfectionFrühphasen menschlicher LeukämienThe anemia of leukemiaClinical manifestations of leukemiaLeukemia: Some Present-Day ProblemsAPLASTIC ANEMIA: AN ANALYSIS OF 50 CASES*DANIEL N. MOHLER, M.D., BYRD S. LEAVELL, M.D., F.A.C.P.Uveoparotitis, skin nodules, azotemia and monocytosisMonocytic leukemiaSymptomatic and hemopathic hemolytic anemia 1 October 1954Volume 41, Issue 4Page: 780-797KeywordsAnemiaBone marrowClinical laboratoriesNeutropeniaResearch laboratoriesSpleen ePublished: 1 December 2008 Issue Published: 1 October 1954 PDF downloadLoading ...