Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay

S could also be important for inducing a metabolic state change as in hibernating animals, by increasing energy storage in the form of reduced cofactors as well as increasing intracellular oxygen. In this review, we bracket luminal free sulfide exposure to colonocytes based on bioenergetic studies on colon-derived cells, discuss the microbial pathways for sulfide generation, and their interplay with dietary sulfur and host oxygen and redox metabolism.