Hormone replacement therapy significantly reduced mean 24-hour systolic blood pressure from 149.3 to 140.3 mm Hg (p<0.001) in postmenopausal women with treated hypertension.
Observational (n=34)
Does a cyclic combination of estradiol and norgestrel reduce mean 24-hour blood pressure in postmenopausal women with treated hypertension?
Hormone replacement therapy with estradiol and norgestrel significantly reduces 24-hour ambulatory blood pressure in postmenopausal women with treated hypertension.
Tasa de eventos absoluta: 140.3% vs 149.3%
valor p: p=< 0.001
BACKGROUND: The rate and severity of hypertension increase dramatically after menopause. Complications seem to be more frequent and marked in hypertensive patients with greater blood pressure (BP) variability, and antihypertensive treatment does not easily reduce this variability. The effect of hormone replacement therapy (HRT) on BP and its variability is not well understood in moderate to severe hypertension, but estrogen may have calcium channel-blocking properties. Cardiovascular events occur more frequently in the morning, likely in part because of a rise in BP. DESIGN: We prospectively studied 34 postmenopausal women with treated hypertension (mean age = 53 years) and receiving a cyclic combination of estradiol and norgestrel for 19 weeks with 24-h ambulatory BP monitoring. RESULTS: Mean daily BP and its variability decreased significantly with HRT (149.3 +/- 6.1 mm Hg vs. 140.3 +/- 8.5 mm Hg p < 0.001; diastolic: 95.4 +/- 4.7 mm Hg vs. 92.4 +/- 7.2 mm Hg p < 0.05). There was also a significant decrease in the early morning BP values after HRT (154.0 +/- 6.9 mm Hg vs. 145.6 +/- 11.0 mm Hg p < 0.001; diastolic: 98.0 +/- 4.8 mm Hg vs. 95.1 +/- 10.0 mm Hg p < 0.05). Subjects who were taking calcium channel blockers (n = 11) had only half the reduction in 24-h systolic BP compared with those who were not taking calcium channel blockers (5.3 mm Hg vs. 10.5 mm Hg), and the reduction in those who were taking calcium channel blockers failed to reach statistical significance. CONCLUSIONS: Our results demonstrate that HRT may have a role in decreasing the severity of hypertension, and the mechanism of its action might be through calcium channels.
Székács et al. (Sat,) conducted a observational in treated hypertension (n=34). Hormone replacement therapy (cyclic combination of estradiol and norgestrel) vs. Baseline (prior to HRT) was evaluated on Mean daily systolic blood pressure (p=< 0.001). Hormone replacement therapy significantly reduced mean 24-hour systolic blood pressure from 149.3 to 140.3 mm Hg (p<0.001) in postmenopausal women with treated hypertension.
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