The combination of high BMI, fatty liver, and high percentage body fat (O + F + P) was significantly associated with an increased risk of type 2 diabetes mellitus (OR 8.07).
Cross-Sectional (n=48,426)
No
Are different combinations of obesity phenotypes associated with the presence of cardiometabolic diseases in adults?
Specific combinations of obesity phenotypes, such as high BMI with fatty liver and high body fat, are strongly associated with specific cardiometabolic diseases like diabetes and metabolic syndrome.
Odds Ratio: 8.07 (95% CI 3.23–20.16)
valor p: p=<0.001
Abstract The prevalence of obesity was increasing and became a growing problem worldwide. Obesity increased the risk of developing metabolic abnormalities and was associated adverse health outcomes. Our aim was to examine the associations among different combinations of obesity phenotypes (high body mass index > 27 kg/m 2 (O), high waist circumference (male > 90 cm, female > 80 cm) (W), fatty liver (F) and percentage body fat in top 40% (P)) and cardiometabolic diseases (type 2 diabetes mellitus (DM), hypertension (HTN), metabolic syndrome (MetS)). A total of 48426 eligible subjects were categorized based on the different definitions. After adjusting for all covariables, participants with O + F + P combination were more likely associated with the presence of DM. Participants with O + W combination were more associated with the presence of HTN than others. Participants with O + W + F + P had higher risk for the presence of MetS than others. The study addressed the associations between different obesity phenotypes and DM and HTN in the adult population. Better understanding the pathophysiological mechanisms underlined individual vulnerability and progression of cardiometabolic insults.
Chen et al. (Tue,) conducted a cross-sectional in Obesity phenotypes and cardiometabolic diseases (n=48,426). Combination of high BMI, fatty liver, and high percentage body fat (O + F + P) vs. Non-obesity was evaluated on Presence of Type 2 Diabetes Mellitus (OR 8.07, 95% CI 3.23-20.16, p=<0.001). The combination of high BMI, fatty liver, and high percentage body fat (O + F + P) was significantly associated with an increased risk of type 2 diabetes mellitus (OR 8.07).