Patients with chronic kidney disease stage 3 had a significantly higher prevalence of carotid plaques compared to controls (58% vs 40%, p=0.002) and greater maximal plaque thickness.
Case-Control (n=321)
Is maximal carotid plaque thickness increased in patients with chronic kidney disease stage 3 compared to controls, and is it associated with cardiovascular disease and arterial calcification?
Maximal carotid plaque thickness is significantly increased in patients with CKD stage 3 compared to controls and correlates with prevalent cardiovascular disease and coronary/carotid calcification.
Tasa de eventos absoluta: 58% vs 40%
valor p: p=0.002
Background Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) was increased in patients with chronic kidney disease compared to controls and associated with cardiovascular disease and severity of calcification in the carotid and coronary arteries. Methods The study group consisted of 200 patients with chronic kidney disease stage 3 from the Copenhagen Chronic Kidney Disease Cohort and 121 age- and sex-matched controls. cPTmax was assessed by ultrasound and arterial calcification by computed tomography scanning. Results Carotid plaques were present in 58% of patients (n = 115) compared with 40% of controls (n = 48), p = 0.002. Among participants with plaques, cPTmax (median, interquartile range) was significantly higher in patients compared with controls (1.9 (1.4–2.3) versus 1.5 (1.2–1.8) mm), p = 0.001. Cardiovascular disease was present in 9% of patients without plaques (n = 85), 23% of patients with cPTmax 1.0–1.9 mm (n = 69) and 35% of patients with cPTmax >1.9 mm (n = 46), p = 0.001. Carotid and coronary calcium scores >400 were present in 0% and 4%, respectively, of patients with no carotid plaques, in 19% and 24% of patients with cPTmax 1.0–1.9 mm, and in 48% and 53% of patients with cPTmax >1.9 mm, p <0.001. Conclusions This is the first study showing that cPTmax is increased in patients with chronic kidney disease stage 3 compared to controls and closely associated with prevalent cardiovascular disease and severity of calcification in both the carotid and coronary arteries.
Bjergfelt et al. (Tue,) conducted a case-control in Chronic kidney disease stage 3 (n=321). Chronic kidney disease stage 3 vs. Age- and sex-matched controls was evaluated on Presence of carotid plaques (p=0.002). Patients with chronic kidney disease stage 3 had a significantly higher prevalence of carotid plaques compared to controls (58% vs 40%, p=0.002) and greater maximal plaque thickness.
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