The ATHOS device showed high agreement with the reference SphygmoCor for measuring pulse wave velocity, with a mean difference of 0.15 m/s and a high correlation (r = 0.959, P < 0.001).
Cross-Sectional (n=90)
Does the ATHOS device accurately measure carotid-femoral pulse wave velocity compared to the reference SphygmoCor device in healthy volunteers?
The ATHOS device is an accurate and reproducible alternative to SphygmoCor for noninvasive assessment of arterial stiffness.
Mean Difference: 0.15
Tasa de eventos absoluta: 7.88% vs 7.72%
valor p: p=<0.001
BACKGROUND: Large artery stiffness, assessed by carotid--femoral pulse wave velocity (cfPWV), is a major risk factor for cardiovascular events, commonly used for risk stratification. Currently, the reference device for noninvasive cfPWV is SphygmoCor but its cost and technically challenging use limit its diffusion in clinical practice. AIM: To validate a new device for noninvasive assessment of cfPWV, ATHOS (Arterial sTiffness faitHful tOol aSsessment), designed in collaboration with the Politecnico di Torino, against the reference noninvasive method represented by SphygmoCor. METHODS: Ninety healthy volunteers were recruited. In each volunteer, we assessed cfPWV, using SphygmoCor (PWVSphygmoCor) and ATHOS (PWVATHOS) devices in an alternate fashion, following the ARTERY Society guidelines. The accuracy was assessed by Bland--Altman plot, and reproducibility was assessed by interoperator correlation coefficient (ICC). RESULTS: Mean PWVATHOS and mean PWVSphygmoCor were 7.88 ± 1.96 and 7.72 ± 1.95 m/s, respectively. Mean difference between devices was 0.15 ± 0.56 m/s, with a high correlation between measurements (r = 0.959, P < 0.001). Considering only PWV values at least 8 m/s (n = 30), mean difference was 0.1 ± 0.63 m/s. The ICC was 97.7% with ATHOS. CONCLUSION: ATHOS showed an excellent level of agreement with SphygmoCor, even at high PWV values, with a good reproducibility. Its simplicity of use could help increase clinical application of PWV assessment, improving patients' cardiovascular risk stratification.
Leone et al. (Tue,) conducted a cross-sectional in Healthy (n=90). ATHOS device vs. SphygmoCor device was evaluated on carotid-femoral pulse wave velocity (cfPWV) (MD 0.15, p=<0.001). The ATHOS device showed high agreement with the reference SphygmoCor for measuring pulse wave velocity, with a mean difference of 0.15 m/s and a high correlation (r = 0.959, P < 0.001).