Unloading the carotid baroreceptors significantly lowered the muscle metaboreflex thresholds for mean arterial blood pressure (662 vs 795 mmHg) and total vascular resistance (P<0.05).
Does unloading the carotid baroreceptors alter the threshold and gain of the muscle metaboreflex in healthy subjects?
Unloading the carotid baroreceptors shifts the pressor threshold of the muscle metaboreflex toward lower metabolic stimulation levels, indicating that the carotid baroreflex normally inhibits the muscle metaboreflex pressor response.
Tasa de eventos absoluta: 662% vs 795%
valor p: p=<0.05
The purpose of the present study was to test our hypothesis that unloading the carotid baroreceptors alters the threshold and gain of the muscle metaboreflex in humans. Ten healthy subjects performed a static handgrip exercise at 50% of maximum voluntary contraction. Contraction was sustained for 15, 30, 45, and 60 s and was followed by 3 min of forearm circulatory arrest, during which forearm muscular pH is known to decrease linearly with increasing contraction time. The carotid baroreceptors were unloaded by applying 0.1-Hz sinusoidal neck pressure (oscillating from +15 to +50 mmHg) during ischemia. We estimated the threshold and gain of the muscle metaboreflex by analyzing the relationship between the cardiovascular responses during ischemia and the amount of work done during the exercise. In the condition with unloading of the carotid baroreceptors, the muscle metaboreflex thresholds for mean arterial blood pressure (MAP) and total vascular resistance (TVR) corresponded to significantly lower work levels than the control condition (threshold for MAP: 795 ± 102 vs. 662 ± 208 mmHg and threshold for TVR: 818 ± 213 vs. 572 ± 292 kg·s, P < 0.05), but the gains did not differ between the two conditions (gain for MAP: 4.9 ± 1.7 vs. 4.4 ± 1.6 mmHg·kg·s −1 ·100 and gain for TVR: 1.3 ± 0.8 vs. 1.3 ± 0.7 mmHg·l −1 ·min −1 ·kg·s −1 ·100). We conclude that the carotid baroreflex modifies the muscle metaboreflex threshold in humans. Our results suggest the carotid baroreflex brakes the muscle metaboreflex, thereby inhibiting muscle metaboreflex-mediated pressor and vasoconstriction responses. NEW & NOTEWORTHY We found that unloading the carotid baroreceptors shifts the pressor threshold of the muscle metaboreflex toward lower metabolic stimulation levels in humans. This finding indicates that, in the normal loading state, the carotid baroreflex inhibits the muscle metaboreflex pressor response by shifting the reflex threshold to higher metabolic stimulation levels.
Ichinose et al. (Fri,) conducted a other in Healthy (n=10). Unloading the carotid baroreceptors vs. Control condition was evaluated on Muscle metaboreflex thresholds for mean arterial blood pressure (MAP) and total vascular resistance (TVR) (p=<0.05). Unloading the carotid baroreceptors significantly lowered the muscle metaboreflex thresholds for mean arterial blood pressure (662 vs 795 mmHg) and total vascular resistance (P<0.05).