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July 20, 1990

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Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

GTGordon TodderudBristol-Myers Squibb (United States)MWMatthew I. WahlCedars-Sinai Medical Center

Sue Goo RheeChonnam National University

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Resumen

Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.

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Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor | Synapse

Cite This Study

Todderud et al. (Fri,) studied this question.

synapsesocial.com/papers/6a20d2def76165bc1becb194 https://doi.org/https://doi.org/10.1126/science.2374928

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.1989 · 387 citations
2Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.1990 · 177 citations
3Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor1989 · 144 citations
4Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.1990 · 134 citations
5Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.1990 · 186 citations