Surface-modified iron oxide nanoprobes in biomedical scaffolds

a salt-leaching/phase-inversion method. Among all tested formulations, SPIONs@Al(OH) demonstrated superior colloidal stability, magnetic responsiveness, and cytocompatibility. When embedded in PU scaffolds, these magnetic nanocomposites exhibited optimal mesoporosity, homogeneous nanoparticle distribution, and efficient magnetic hyperthermia performance under clinically relevant alternating magnetic fields. This work highlights the synergistic potential of material design and surface engineering in developing next-generation implantable platforms for targeted oncological treatment.