In men with Type 1 diabetes, higher glycaemic variability was significantly associated with the presence of coronary artery calcium (OR 4.7; 95% CI 1.1-19.7), whereas no association was seen in women.
Cross-Sectional (n=75)
Is glycaemic variability associated with the presence of coronary artery calcium in adults with Type 1 diabetes?
Subclinical atherosclerosis, measured by coronary artery calcium, is associated with higher glucose levels and greater glycaemic variability in men with Type 1 diabetes, but not in women.
Odds Ratio: 4.7 (95% CI 1.1–19.7)
AIMS: We investigated coronary artery calcium in association with glucose levels and variability measured using continuous glucose monitoring in adults with Type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. METHODS: Coronary artery calcium was measured by electron beam tomography. The presence of any coronary artery calcium was analysed with respect to glucose levels mean(T) (mean glucose), % of values 10 mmol/l and either 10 mmol/l and glycaemic variability sd(T) (sd of all glucose values); sd(dm) (sd of the daily mean glucose levels) and sd(hh:mm) (glucose sd for a specified time of day, over all days) using 3-5 days of continuous glucose monitoring from 75 subjects (45 women, 30 men), age 42 ± 9 years (mean ± sd) and diabetes duration of 29 ± 8 years using logistic regression. RESULTS: We observed significant associations between coronary artery calcium and mean(T) (OR = 4.4, 95% CI 1.1-18.6), % of values > 10 mmol/l (OR = 5.5, 95% CI 1.3-22.6), % of measures 10 mmol/l (OR = 5.7, 95% CI 1.3-24.9), sd(T) (OR = 4.7, 95% CI 1.1-19.7), sd(dm) (OR = 6.0, 95% CI 1.2-30.4) and sd(hh:mm) (OR = 4.0, 95% CI 1.1-15.4), among men, but none of these variables were associated with the presence of coronary artery calcium in women. CONCLUSIONS: We report the novel finding that subclinical atherosclerosis is associated with glucose levels and variability in men with Type 1 diabetes. The relationship of coronary artery calcium and glucose variability in Type 1 diabetes, and potential gender differences in this association, deserve further study.
Snell‐Bergeon et al. (Tue,) conducted a cross-sectional in Type 1 diabetes (n=75). Glycaemic variability and glucose levels was evaluated on Presence of any coronary artery calcium (OR 4.7, 95% CI 1.1-19.7). In men with Type 1 diabetes, higher glycaemic variability was significantly associated with the presence of coronary artery calcium (OR 4.7; 95% CI 1.1-19.7), whereas no association was seen in women.