In patients with hypertrophic cardiomyopathy, the presence of myocardial hyperintensity on T2-STIR magnetic resonance was strongly associated with non-sustained ventricular tachycardia (OR 165).
Cross-Sectional (n=65)
Sí
Does myocardial hyperintensity on T2-STIR CMR associate with ventricular electrical instability and advanced disease in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, myocardial hyperintensity on T2-STIR CMR is strongly associated with non-sustained ventricular tachycardia and advanced disease features.
Odds Ratio: 165 (95% CI 11–2455)
Tasa de eventos absoluta: 77.8% vs 2.6%
valor p: p=<0.001
BACKGROUND: Myocardial hyperintensity on T2-weighted short-tau inversion recovery (STIR) (HyT2) cardiac magnetic resonance (CMR) images has been demonstrated in patients with hypertrophic cardiomyopathy (HCM) and is considered a sign of acute damage. The aim of the current study was to evaluate the relationship between HyT2 and both a) markers of ventricular electrical instability and b) clinical and CMR parameters. METHODS: Sixty-five patients underwent a thorough clinical examination, consisting of 24-h ECG recording and CMR examination including functional evaluation, T2-STIR images and late gadolinium enhancement (LGE). RESULTS: HyT2 was detected in 27 patients (42%), and subjects with HyT2 showed a greater left ventricle (LV) mass index (p<0.001), lower LV ejection fraction (p = 0.05) and greater extent of LGE (p<0.001) compared to those without HyT2. Twenty-two subjects (34%) presented non-sustained ventricular tachycardia (NSVT) on the 24-h ECG recording, 21 (95%) of whom exhibited HyT2. Based on the logistic regression analysis, HyT2 (odds ratio OR: 165, 95% CI 11-2455, p<0.001) and LGE extent (1.1, 1.0-1.3, p<0.001) served as independent predictors of NSVT, while the presence of LGE was not associated with NSVT occurrence (p = 0.49). The presence of HyT2 was associated with lower heart rate variability (p = 0.006) and a higher number of arrhythmic risk factors (p<0.001). CONCLUSIONS: In HCM patients, HyT2 upon CMR examination is associated with more advanced disease and increased arrhythmic burden.
Todiere et al. (Thu,) conducted a cross-sectional in Hypertrophic Cardiomyopathy (n=65). Myocardial hyperintensity on T2-weighted short-tau inversion recovery (HyT2) vs. Absence of HyT2 was evaluated on Non-sustained ventricular tachycardia (NSVT) on 24-h ECG recording (OR 165, 95% CI 11-2455, p=<0.001). In patients with hypertrophic cardiomyopathy, the presence of myocardial hyperintensity on T2-STIR magnetic resonance was strongly associated with non-sustained ventricular tachycardia (OR 165).