Highly Diastereo‐ and Enantioselective Direct Aldol Reactions in Water

Going green: The synthetically very important aldol reaction can proceed in water without a metal catalyst with excellent enantioselectivity. The key to the reaction is a small, synthetic organic catalyst based on trans-hydroxyproline with a siloxy group. Thus, this method is an environmentally friendly process for the synthesis of chiral molecules. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2006/z502488ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.