What question did this study set out to answer?

This artifact aims to provide the source code for developing imputation models used in multi-ancestry proteome-wide association studies.

June 4, 2026Open Access

BLISS: source code accompanying Large-scale imputation models for multi-ancestry proteome-wide association analysis

Puntos clave

This artifact aims to provide the source code for developing imputation models used in multi-ancestry proteome-wide association studies.
Development of BLISS PWAS models
Implementation of PWAS association testing and Mendelian randomization
Construction of a simulation framework for method validation
The code enables replication of model testing and results validation.
Supports comprehensive analyses across diverse ancestries in proteomics.

Resumen

This artifact archives the code used to develop the BLISS PWAS models reported in the manuscript, plus the immediate downstream pipeline (PWAS association testing, Mendelian randomization, colocalization) and the simulation framework that underpins the method-validation results.

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