Restenosis after Angioplasty in Patients with Left Ventricular Dysfunction

Clinical and angiographic rates of restenosis after angioplasty were compared in 80 patients (group A) with ejection fractions below 40% (mean, 28.3% ± 5.2%) and 50 (group B) with ejection fractions above 50% (mean, 58% ± 5.4%). Mean angina class improved to the same degree in both groups after angioplasty. Recurrence of significant angina within 6 to 12 months affected 30 patients (38%) in group A compared to 12 (24%) in group B (p > 0.05). Angiographic restenosis occurred in 42 patients (53%) in group A compared to 14 (28%) in group B (p = 0.006). Restenosis after single-vessel angioplasty was 46% in group A and 25% in group B (p > 0.05), after multivessel angioplasty it was 62% in group A and 33% in group B (p = 0.05). In group A, restenosis was more frequent in the left anterior descending coronary artery (46%) compared to the right coronary (41%) or circumflex (30%). Higher rates of restenosis occurred in patients with prior coronary artery bypass grafting (64%) or recanalization of chronic total occlusion (61%). Angina was a less reliable indication of restenosis in group A. We attribute the higher rate of restenosis in patients with low ejection fractions partly to low coronary perfusion pressure.