CuH‐Catalyzed Asymmetric Conjugate Reductions of Acyclic Enones

A powerful new reaction has been developed for the asymmetric 1, 4-reduction of prochiral enones (see scheme). The key ingredients in this exceedingly mild and straightforward procedure are catalytic quantities of CuH, a readily available nonracemic phosphane ligand such as that shown, and inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric source of hydride. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2003/z52313ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.