The Unresponsiveness of Lipid Metabolism in Canine Mesenteric Adipose Tissue to Biogenic Amines and to Sympathetic Nerve Stimulation

Abstract The net release or uptake of glycerol and free fatty acids by adipose tissue in perfused mesentery of dogs was determined a) during stimulation of the superior mesenteric nerves and b) following intra‐arterial injection of noradrenaline, 5‐hydroxytryptamine, histamine and compound 48/80. Nerve stimulation had no observable effect on lipolysis, a finding which is in contrast to previously reported results from subcutaneous adipose tissue. Moreover, in order to evoke lipolysis, noradrenaline and histamine had to be administered in amounts over 10 times higher than required for subcutaneous adipose tissue. Compound 48/80, a mast cell‐depleting agent, and 5‐hydroxytryptamine did not increase lipolysis. It is concluded that mesenteric adipose tissue may not be influenced by the same agents for lipolysis as subcutaneous adipose tissue from the same species.