Children with a parental history of coronary artery disease had significantly higher serum lipoprotein (a) (30.3 vs 24.1 mg/dl) and total cholesterol (190 vs 150 mg/dl) compared to controls.
Case-Control (n=100)
No
Do children of parents with premature CAD have higher serum lipoprotein (a) and total cholesterol levels compared to children of parents without CAD?
Children of parents with premature CAD exhibit significantly elevated levels of lipoprotein (a) and total cholesterol, highlighting the potential value of early lipid screening in this high-risk population.
Tasa de eventos absoluta: 30.3% vs 24.1%
valor p: p=<0.001
: More and more Indians are falling prey to coronary artery (CAD) which is one of the genetic diseases attributed to numerous gene-environment interactions. There are various reasons for this including a sedentary lifestyle, genetic predisposition, pollution, smoking, drinking, a fatty diet and a general ignorance about what causes heart ailments. In India, 10% of the present infant mortality may be accounted for by CAD. This study was conducted to take appropriate measurements in the children of parents with diagnosed of CAD who are at high risk in relationship to serum Lp (a) and total cholesterol. Two groups 50 each of both sexes between 5-18 years children were compared for the risk factors of CAD and data was analysed statistically by using student’s t test and Pearson correlation coefficient analysis. : It shows that Group A had increased values of serum Lp (a) and total cholesterol (p0.001) than Group B. Diastolic BP values were also significantly higher in Group A children. In addition, Lp (a) level was directly corelated with total cholesterol levels (r=0.734; p0.001). : The familial environment pay a very important role for the severity of CAD in childhood and children of CAD parents should be screened regularly. It also serves as an important diagnostic marker of CAD in youth at early stage.
Saxena et al. (Sat,) conducted a case-control in Coronary artery disease risk (n=100). Parental history of coronary artery disease vs. No parental history of coronary artery disease was evaluated on Serum lipoprotein (a) level (mg/dl) (p=<0.001). Children with a parental history of coronary artery disease had significantly higher serum lipoprotein (a) (30.3 vs 24.1 mg/dl) and total cholesterol (190 vs 150 mg/dl) compared to controls.