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Minocycline induces vasodilation in isolated pulmonary arteries through both endothelium-dependent and -independent mechanisms, inhibiting endothelin-1-induced contraction. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 4, 2026Open Access

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Minocycline inhibits endothelin-1-induced contraction in isolated pulmonary artery

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(72.7 mM)-induced precontraction. In endothelium-intact IPAs, indomethacin (10 μM) significantly inhibited the relaxation. We revealed for the first time that minocycline indues vasodilation through both endothelium-dependent and -independent mechanisms in isolated IPAs.

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Niijima et al. (Sat,) studied this question.

synapsesocial.com/papers/6a21c6784c1bee377ceca9ed https://doi.org/https://doi.org/10.1016/j.jphs.2026.04.001

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