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Molecular control of nitric oxide synthases in the cardiovascular system | Synapse

August 15, 1999Open Access

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Molecular control of nitric oxide synthases in the cardiovascular system

APAndreas PapapetropoulosUniversity of Siena

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Resumen

Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the regulation of the three nitric oxide synthase isoforms in the cardiovascular system are examined at molecular and cellular levels. In addition, recent information gleaned from the use of NOS knockout mice are discussed.

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Andreas Papapetropoulos (Sun,) studied this question.

synapsesocial.com/papers/6a21e66fc9fa6b7ac4d8532d https://doi.org/https://doi.org/10.1016/s0008-6363(99)00161-3

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.1993 · 777 citations
2Signaling Vascular Morphogenesis and Maintenance1997 · 1,201 citations
3Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro.1997 · 119 citations
4Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.1995 · 588 citations
5Nitric oxide as a secretory product of mammalian cells1992 · 4,388 citations