Factors Influencing Green Purchasing Behaviors: Some Insights from Tamale, Ghana

INTRODUCTION: Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. MATERIAL AND METHODS: A total of 30 male Sprague-Dawley rats were divided into 3 groups. The first group constituted the control group. The second group was given RESULTS: For group 2, the CONCLUSIONS: Administration of ZA had nephrotoxic effects on rat kidney observed under both light and electron microscopy. Concomitant administration of Vit-E significantly reduces toxic histopathological effects of ZA.