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June 5, 2026Journal of the American College of Cardiology204 citations

Electrocardiographic Criteria for the Diagnosis of Left Ventricular Hypertrophy

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JPJulio G. PegueroSPSaberio Lo PrestiJPJorge Pérez

Key Result

The proposed ECG criteria for the diagnosis of left ventricular hypertrophy improved the sensitivity and overall accuracy of the test.

Key Points

  • To improve the diagnostic performance of electrocardiographic criteria for left ventricular hypertrophy.
  • Divided into test and validation cohorts, with 94 patients analyzed.
  • Measured left ventricular mass index using echocardiography.
  • Conducted area under the curve analysis and McNemar test for diagnostic agreement.
  • Proposed ECG criteria improved sensitivity for diagnosing LVH.
  • Overall accuracy of ECG testing was enhanced.
  • Agreement with left ventricular mass index was statistically significant.

Study Design

Type

Cohort (n=94)

Structured PICO

Do the proposed ECG criteria improve the sensitivity and overall accuracy for diagnosing left ventricular hypertrophy compared to current criteria?

P
Population
94 patients, including 47 with hypertensive crisis and 47 with normal blood pressure at admission, evaluated for left ventricular hypertrophy.
E
Exposure
Proposed ECG criteria involving measuring the amplitude of the deepest S wave
C
Comparator
Current ECG criteria, using echocardiography-estimated left ventricular mass index as the reference standard
O
Outcome
Diagnostic performance (sensitivity and overall accuracy) for left ventricular hypertrophysurrogate

A new ECG criterion based on the deepest S wave improves the sensitivity and accuracy of diagnosing left ventricular hypertrophy.

Abstract

BACKGROUND: Current electrocardiographic (ECG) criteria for the diagnosis of left ventricular hypertrophy (LVH) have low sensitivity. OBJECTIVES: The goal of this study was to test a new method to improve the diagnostic performance of the electrocardiogram. METHODS: The study was divided into 2 groups, a test and a validation cohort. In the test cohort, 94 patients were analyzed, including 47 with the diagnosis of hypertensive crisis and 47 with normal blood pressure at admission. Echocardiography was used to estimate the left ventricular mass index. Area under the curve (AUC) analysis was used for comparison of single and combined leads. The McNemar test was used to assess agreement among the ECG criteria against the left ventricular mass index. The proposed ECG criteria involved measuring the amplitude of the deepest S wave (S RESULTS: The S CONCLUSIONS: The proposed criteria for the ECG diagnosis of LVH improved the sensitivity and overall accuracy of the test.

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Cite This Study

Peguero et al. (2017) conducted a cohort in Left ventricular hypertrophy (n=94). Proposed ECG criteria vs. Current ECG criteria was evaluated on Sensitivity and overall accuracy. The proposed ECG criteria for the diagnosis of left ventricular hypertrophy improved the sensitivity and overall accuracy of the test.

synapsesocial.com/papers/6a224027c89b699089971fechttps://doi.org/10.1016/j.jacc.2017.01.037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Newly proposed electrocardiographic criteria for the diagnosis of left ventricular hypertrophy in a Chinese population2018 · 26 citations
  2. 2Performance of Electrocardiographic Criteria for Echocardiographically Diagnosed Left Ventricular Hypertrophy in Chinese Hypertensive Patients2020 · 26 citations
  3. 3The Role of ECG in the Diagnosis of Left Ventricular Hypertrophy2014 · 74 citations
  4. 4ECG-based detection of left ventricle hypertrophy2015 · 9 citations
  5. 5Electro‐ and echocardiographic features of left ventricle hypertrophy in patients with hypertrophic cardiomyopathy2022 · 5 citations