Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1.

Previously, we have found that in perfused rat hearts, isoproterenol and prostaglandin E1 (PGE1) caused comparable increases in CAMP and activations of protein kinase but that only isoproterenol led to the phosphorylation of several substrates of protein kinase (Hayes,