Hyperinsulinaemia in women with polycystic ovary syndrome is associated with adverse risk factors for coronary artery disease, particularly reduced HDL2 concentrations.
Highlights the link between hyperinsulinaemia in PCOS and adverse cardiovascular risk profiles, emphasizing the need to understand its role in heart disease.
In the polycystic ovary syndrome, hyperinsulinaemia is commonly found in women with hirsutism, oligomenorrhoea and acanthosis nigricans and this subset of patients possess adverse risk factors for coronary artery disease, particularly reduced HDL2 concentrations. Conversely, raised serum insulin concentrations are not common in women with PCOS in whom raised serum LH concentrations or regular menstrual cycles are present. We postulate that both direct ovarian and indirect actions of insulin (through changes in IGFI-I, IGFBP-I and SHBG concentrations) play important roles in determining androgen concentrations in women. Many intriguing questions follow from this link between the control of nutrition and reproduction and many old observations required re-examination in this new light. Vital to our understanding in this field will be the cause of moderate hyperinsulinaemia, the action of insulin on the normal ovary, and the importance of adverse surrogate risk factors for heart disease in hyperinsulinaemic women.
Conway et al. (Wed,) conducted a review in Polycystic ovary syndrome. Hyperinsulinaemia was evaluated. Hyperinsulinaemia in women with polycystic ovary syndrome is associated with adverse risk factors for coronary artery disease, particularly reduced HDL2 concentrations.
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