Population
Control and cardiomyopathic Syrian hamsters (neonatal, young, and aging/terminal disease stages)
Comparison
Intraperitoneal tracer dose of… vs Control Syrian hamsters
Design
Preclinical
Key result
In young hamsters, the rate constant for myocardial norepinephrine turnover was significantly higher in those with mild cardiac hypertrophy compared to controls (0.102 vs 0.064 hours-1, P<0.001).
Authors
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Early sympathetic activation in hamster hypertrophy models warrants mechanistic follow-up; leaves open translation to human HF therapies.
Absolute Event Rate: 0.102% vs 0.064%
p-value: p=<0.001
In cardiomyopathic hamsters, a progressive increase in cardiac sympathetic tone leads to decreased cardiac norepinephrine stores, contributing to the development of congestive heart failure.
Sole et al. (1975) studied Cardiomyopathy. Cardiomyopathy vs. Control hamsters was evaluated on Rate constant (K) for myocardial norepinephrine turnover (p=<0.001). In young hamsters, the rate constant for myocardial norepinephrine turnover was significantly higher in those with mild cardiac hypertrophy compared to controls (0.102 vs 0.064 hours-1, P<0.001).