An increase in serial serum monomeric periostin level was associated with lower 3-month survival compared to a decrease (36% vs 92.3%, P=0.002) in patients with AE-FIP.
Cohort (n=37)
Does serial change in serum monomeric periostin level predict 3-month survival in patients with acute exacerbation of chronic fibrosing interstitial pneumonia?
Serial change in serum monomeric periostin level may serve as a prognostic indicator for 3-month survival in patients with acute exacerbation of chronic fibrosing interstitial pneumonia.
Odds Ratio: 12.4 (95% CI 0.82–187.9)
Tasa de eventos absoluta: 36% vs 92.3%
valor p: p=0.069
Background: The associations of serum monomeric periostin (M-PN) level and serial change in M-PN with acute exacerbation of chronic fibrosing interstitial pneumonia (AE-FIP) are unclear.Methods: We prospectively measured serum M-PN level from onset of AE to day 14 in 37 patients with AE-FIP and evaluated its association with outcome. To determine localization of periostin expression, immunohistochemical staining of pathological lung tissue from autopsy cases of AE-IPF was evaluated.Results: Data from 37 AE-FIP patients (28 men; age 73.9±7.8 years) were analyzed. With healthy controls as reference, serum M-PN level was significantly higher in patients with AE-FIP (P=0.02) but not in those with stable idiopathic pulmonary fibrosis (P=1.00). M-PN was significantly lower on day 7 than at AE-FIP onset in survivors 14.6±5.8 vs. 9.3±2.8 ng/mL (onset to day 7: P<0.001) but not in non-survivors 14.6±5.1 vs. 13.2±5.1 ng/mL (onset to day 7: P=0.07). In analysis using a cut-off value for serial change in M-PN (ΔM-PN), 3-month survival was 92.3% in the ΔM-PN decrease group and 36% in the ΔM-PN increase group (P=0.002). In multivariate analysis, 3-month survival tended to be associated with high ΔM-PN (OR: 12.4, 95% CI: 0.82–187.9, P=0.069).Conclusions: Serial change in serum M-PN level may be a prognostic indicator of AE-FIP.
Shimizu et al. (Sat,) conducted a cohort in Acute exacerbation of chronic fibrosing interstitial pneumonia (AE-FIP) (n=37). Increase in serial serum monomeric periostin (M-PN) level vs. Decrease in serial M-PN level was evaluated on 3-month survival (OR 12.4, 95% CI 0.82-187.9, p=0.069). An increase in serial serum monomeric periostin level was associated with lower 3-month survival compared to a decrease (36% vs 92.3%, P=0.002) in patients with AE-FIP.
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