Artificial intelligence models for predicting acute kidney injury in the intensive care unit: a systematic review of modeling methods, data utilization, and clinical applicability

Objectives: Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with high mortality, prolonged ICU stays, and increased costs. Early prediction is crucial for timely intervention and improved outcomes. Various prediction models, including machine learning, deep learning, and dynamic prediction frameworks, have been developed, but their modeling approaches, data utilization, and clinical applicability require further investigation. This review comprehensively assesses the modeling methods, data utilization strategies, and clinical applicability of AKI prediction models in the ICU, identifies current challenges, and proposes future research directions. Materials and Methods: A systematic search was conducted in PubMed, Embase, Scopus, Web of Science, IEEE Xplore, and ACM Digital Library up to December 12, 2024. Studies were included if they reported AKI prediction models using ICU-specific data, included at least 2 predictors, and evaluated model performance. Extracted data included study characteristics, model details, data sources, performance metrics, and validation methods. The risk of bias was assessed using PROBAST (Prediction Model Risk of Bias Assessment Tool), and the reporting quality was evaluated using the TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) guideline. Results: = 44) had a high risk of bias, particularly in generalizability and clinical applicability. Discussion: Although AI models have shown promise in predicting AKI in ICU settings, key challenges remain. These include limited external validation, lack of dynamic modeling, insufficient interpretability, and poor consideration of clinical integration. Different study designs, prediction windows, and data sources also hinder model comparability. Conclusions: Future research should prioritize dynamic, interpretable, and externally validated models. These efforts are critical to bridge the gap between model development and clinical implementation and to enhance the real-world applicability of AI in AKI prediction.