Dobutamine stress-echocardiography reproduced a dynamic left ventricular outflow tract gradient of 250 mmHg, revealing previously undiagnosed hypertrophic cardiomyopathy with latent obstruction.
Case Report (n=1)
No
In patients with takotsubo cardiomyopathy complicated by LVOT obstruction, dobutamine stress-echocardiography and endomyocardial biopsy can identify underlying latent hypertrophic cardiomyopathy, guiding appropriate beta-blocker therapy.
A 62-year-old woman with takotsubo cardiomyopathy (TCM) accompanied by cardiogenic shock due to the obstruction of left ventricular outflow tract (LVOT) and massive mitral regurgitation (MR) was admitted to the emergency department. After successful treatment with intensive care, dobutamine stress-echocardiography was performed, which reproduced a dynamic LVOT gradient, severe MR and cardiogenic shock. A histological examination obtained from the right ventricular septum demonstrated hypertrophied and bizarre myocytes, with myocyte disarray. Besides TCM, a diagnosis of preexisting hypertrophic cardiomyopathy with latent obstruction was made. She was discharged with medical therapy including a beta-blocker, which would not be routinely employed in the treatment of a patient with TCM.
Arakawa et al. (Tue,) conducted a case report in Takotsubo cardiomyopathy with cardiogenic shock (n=1). Dobutamine stress-echocardiography and endomyocardial biopsy was evaluated. Dobutamine stress-echocardiography reproduced a dynamic left ventricular outflow tract gradient of 250 mmHg, revealing previously undiagnosed hypertrophic cardiomyopathy with latent obstruction.