Chronic blockade of the renin-angiotensin system with valsartan or benazeprilat lowered blood pressure, prevented proteinuria, prolonged survival, and decreased end-organ damage in stroke-prone SHR.
Does chronic blockade of the renin angiotensin system with valsartan or benazeprilat improve survival, blood pressure, and end-organ damage in salt-loaded stroke-prone spontaneously hypertensive rats?
In a rat model of severe hypertension, both angiotensin receptor blockade (valsartan) and ACE inhibition (benazeprilat) provided similar protection against mortality, hypertension, and end-organ damage.
These experiments examined the effectiveness of chronic blockade of the renin angiotensin system with either valsartan or benazeprilat on survival, blood pressure and end-organ damage in salt-loaded stroke-prone SHR. Valsartan or benazeprilat given continuously by subcutaneous osmotic minipump beginning at 10.5 weeks of age lowered blood pressure, as determined by radiotelemetry, prevented proteinuria, prolonged survival and decreased the severity of histopathological changes in the heart and kidney. These results indicate that angiotensin receptor blockade affords a similar degree of protection as inhibition of angiotensin converting enzyme in salt-loaded stroke-prone SHR. Furthermore, our results are consistent with a primary contribution of angiotensin II to the maintenance of blood pressure and support a principal role for angiotensin II-dependent mechanisms in the development of end-organ damage in the salt-loaded stroke-prone SHR.
Webb et al. (Thu,) conducted a other in Salt-loaded stroke-prone spontaneously hypertensive rats. Valsartan or benazeprilat was evaluated on Survival, blood pressure, and end-organ damage. Chronic blockade of the renin-angiotensin system with valsartan or benazeprilat lowered blood pressure, prevented proteinuria, prolonged survival, and decreased end-organ damage in stroke-prone SHR.