BMI-Dependent Correlations of Sex Hormone Genes with Simple Endometrial Hyperplasia

The aim of the work was to identify the features of associations of single nucleotide polymorphisms (SNPs) that determine the level of sex hormones in the body with simple endometrial hyperplasia without atypia (EnHs) in women with different body mass index (BMI). Two groups of BMI-differing subjects (BMI T] ZKSCAN5, rs148982377 T>C ZNF789, rs11031002 T>A FSHB, rs11031005 T>C FSHB, rs112295236 C>G SLC22A10, rs117145500 A>C CHD9, rs727428 C>T SHBG, rs1641549 C>T TP53, rs117585797 C>A ANO2 were considered by us. In general, in the studied sample (EnHs/control, n = 1493), an association of interactions of rs148982377 T>C ZNF789 × BMI with EnHs (OR = 1.11) was revealed. As a result of a comparative analysis, we found that rs148982377 T>C ZNF789 was associated with EnHs in women with a BMI ≥ 25 (OR = 1.77) and was not linked with the disease in women with a BMI A] FSHB (OR = 0.43 and OR = 0.46 respectively) and rs11031005 T>C FSHB (OR = 0.46 and OR = 0.58 respectively)). At the same time, in the BMI ≥ 25 cohort, the risk effect of the TT*rs11031002-rs11031005 haplotype (OR = 3.27) was more pronounced, and the contribution of interlocus interactions of sex hormone genes with EnHs formation was more significant (7 SNPs in 12 models) than in the BMI C] ZNF789 was associated with EnHs in women with a BMI ≥ 25 and was not linked with the disease in women with a BMI < 25.