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Compared with sixteen control animals infused with saline, plasma renin-substrate concentration increased twofold (P < 0.001) in twenty-two rats following infusion of angiotensin II at a mean rate of 191 ng kg−1 min−1 for 13 h. 2. The change was not attributable to an overall increase of plasma protein concentration.
Khayyall et al. (Mon,) studied this question.