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September 1, 1985Open Access

Polyglutamation of methotrexate. Is methotrexate a prodrug?

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Resumen

La polyglutamation est assuree par la folyl polyglutamyl synthetase. Leur etude decrit l'importance pharmacologique de la polyglutamation du methotrexate

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Cite This Study

Chabner et al. (Sun,) studied this question.

synapsesocial.com/papers/6a23728705f676cb2cfb4895 https://doi.org/https://doi.org/10.1172/jci112088

Polyglutamation of methotrexate. Is methotrexate a prodrug? | Synapse

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.1985 · 71 citations
2Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.1983 · 104 citations
3Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro.1984 · 102 citations
4Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell1968 · 377 citations
5Evidence for the Cytotoxic Activity of Polyglutamate Derivatives of Methotrexate1980 · 154 citations