What We Still Don’t Know About Biofilms—Current Overview and Key Research Information

The existence of biofilms as heterogeneous structures, comprising bacterial cells embedded in a self-synthesized polymeric matrix and adhered to biotic and abiotic surfaces, exhibiting high antibiotic tolerance, is a fact that, in recent years, has exerted selective pressure on healthcare systems with the emergence of numerous infections. This review provides a historical overview of the emergence of biofilms, the latest insights into their functionality and distribution, as well as data on innovative strategies to combat them. Special attention is given to significant diseases caused by biofilms, alongside current data on the molecular mechanisms underpinning their tolerance and resistance.