(621) Surgical Outcomes in Patients Under 50 Years of Age with Peyronie’s Disease

Abstract Introduction Peyronie’s disease (PD) is characterized by the formation of fibrotic plaques in the tunica albuginea and is associated with penile pain, palpable nodules, curvature, and erectile dysfunction. Previous studies have reported the prevalence of PD across age groups as 1.5% in those aged 30–39 years, 3% in 40–49 years, 3% in 50–59 years, 4% in 60–69 years, and 6.5% in those aged 70 years and above. Peyronie’s disease is not often encountered in men younger than 50. Objective Reports focusing on these younger patients are scarce in the current literature. To address this gap, we reviewed the records of men under 50 who underwent surgery for chronic-phase Peyronie’s disease between 2006 and 2024. Methods Patients younger than 50 years who presented with Peyronie’s disease and underwent surgery were retrospectively evaluated. A total of 42 patients were included in the study and analyzed in terms of demographic characteristics, disease-related data, type of surgery (shortening procedures, lengthening procedures, penile prosthesis implantation), and postoperative outcomes (complications and satisfaction). Deformities greater than 60 degrees, hourglass deformity, notching deformity, and multiplanar curvature were considered complex deformities. Patient satisfaction was assessed through telephone interviews. For satisfaction evaluation, patients were asked to score on a Likert scale from 1 to 5 (1:not satisfied at all, 5: very satisfied);a score of 3 or higher was regarded as satisfactory. Results The mean age of the patients was 40.6 ± 8.4 years. Fifteen patients had comorbidities (such as hypertension or diabetes), and 24 patients were smokers. Lengthening procedures were performed in 20 patients (48%), shortening procedures in 18 patients (43%), and penile prosthesis implantation in 4 patients (9%). The mean degree of penile curvature was 48.4 ± 14.3. When evaluated separately by groups, the mean curvature was 49° in patients who underwent shortening procedures, 48.5° in those who underwent lengthening procedures, and 46.25° in those who underwent penile prosthesis implantation. Seventeen patients (40%) had dorsal curvature, followed by left lateral in 12 patients (29%), ventral in 7 patients (17%), and right lateral in 6 patients (14%). Complex deformity was identified in 18 patients (43%). Within this subgroup, the majority underwent lengthening procedures (n = 12, 67%), while 5 patients (28%) underwent shortening procedures and 1 patient (5%) received penile prosthesis implantation. The mean follow-up period was 45.2 ± 31.5 months. Complete correction of curvature without residual deformity was achieved in 34 patients (81%). Full correction was observed in all patients who underwent penile prosthesis implantation (n = 4), while the rates were 80% (n = 16) in the lengthening group and 77% (n = 14) in the shortening group. Regarding overall patient satisfaction, the rate was 100% (n = 4) in the penile prosthesis implantation group, 80% (n = 16) in the lengthening group, and 66% (n = 12) in the shortening group. Conclusions The findings indicate that surgical intervention in this age group provides successful anatomical correction and overall high patient satisfaction Disclosure No