Is the class A macrophage scavenger receptor (SR-A) multifunctional? — The mouse’s tale

SR-A ligands Ligand Non-ligand Oxidized Low Density Lipoprotein (LDL) Native LDL Acetylated LDL Oxidized High Density Lipoprotein (HDL) Native HDL Maleylated bovine serum albumin (BSA) BSA Malondialdehyde BSA Fucoidan Heparin Dextran Sulfate Chondroitan Sulfate Polyguanylic acid (poly G) Polycytidylic acid (poly C) Polyinosinic acid (poly I) Polyadenylic acid (poly A) Crocidolite asbestos Silica Lipopolysaccharide (LPS) Lipoteichoic acid (LTA) Gram negative bacteria Gram positive bacteria Apoptotic cells Receptor recognition or nonrecognition has been shown for these molecules, either through direct binding studies or the inhibition of modified lipoprotein endocytosis.