Recent Advances in the Identification of γ-Secretase Inhibitors To Clinically Test the Aβ Oligomer Hypothesis of Alzheimer’s Disease

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTRecent Advances in the Identification of γ-Secretase Inhibitors To Clinically Test the Aβ Oligomer Hypothesis of Alzheimer's DiseaseAnthony F. Kreft, Robert Martone, and Alexander Porte*View Author Information Wyeth Research, CN 8000, Princeton, New Jersey 08543*To whom correspondence should be addressed. Telephone: 732-274-4559. Fax: 732-274-4505. E-mail: email protectedCite this: J. Med. Chem. 2009, 52, 20, 6169–6188Publication Date (Web):August 20, 2009Publication History Received17 February 2009Published online20 August 2009Published inissue 22 October 2009https://pubs.acs.org/doi/10.1021/jm900188zhttps://doi.org/10.1021/jm900188zreview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views3972Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Central nervous system,Peptides and proteins,Redox reactions,Rodent models,Screening assays Get e-Alerts