Understanding HPV Mitigation Content in Highly Engaged YouTube Videos: A Mixed-Method Topic Modeling and Sentiment Analysis of Videos and Related Comments Study

= 3, 15%). Constructs of perceived severity, perceived susceptibility to HPV, and perceived benefits of health behaviors were present in over 80% of videos, whereas self-efficacy was mentioned in only 45%. Topic modeling of comments identified four major themes: knowledge (43.36%), screening and treatment (27.67%), vaccination (16.58%), and alternative treatment (12.38%). These findings highlight that medical professionals were the primary creators and figures in HPV-related YouTube communication. Health behaviors received limited emphasis. Comments revealed notable disagreement and skepticism toward recommended health behaviors and frequent promotion of alternative treatments, highlighting the need for more engaging, trust-building, and behaviorally focused HPV communication on social media.