Predictions and Solutions for Microtubule Curvature Modulation: Anesthesia, Neuroprotection, and Tauopathies via Contact-Geometric Operator Analysis (TOGT/GTCT — Domain 3 of 3)

Applies the TOGT/GTCT contact-geometric framework to model microtubule dynamic instability as an operator sequence G = U∘F∘K∘C on a dm³ contact manifold. Derives three falsifiable classical predictions: (P1) anesthetic binding produces a measurable downward shift ΔκMT linear in MAC; (P2) epothilone B LORR delay is proportional to κ elevation with proportionality constant derivable from the dm³ Lipschitz bound; (P3) the dose-response functional form is identical (up to morphism scaling) to the riboswitch OFF-lock curve (Domain 1). All predictions are classically falsifiable without quantum measurement. Extends to tauopathies and TBI. Part of the Principia Orthogona series. XII Bienal da SBM, Natal, 2026.