Based on the first principle of the ontology of cognitive succession (the essence of cognition is succession), this paper strictly deduces from the three-layer isomorphic spatiotemporal rules of ontology-physics-logic to generate a universally applicable meta-methodology for complex system evolution. This method extracts three basic axioms: irreversibility of evolution, homologous breakpoints, and three types of cognitive deviation, constructs a six-step standardized system regulation operation paradigm, and establishes quantitative judgment standards for cognitive coverage rate and cognitive deviation rate. From the ontological root, it clarifies that all practical problems of complex systems originate from the homologous element association breakpoints caused by human cognitive deviation. Completing breakpoints and calibrating deviations are the only paths for the system to return to the steady state of unity-in-difference and synergy. This meta-methodology breaks the disciplinary barriers between natural sciences, life sciences, engineering technology, and social sciences and humanities. It can be uniformly used for etiological diagnosis, scheme derivation, and AI-assisted experimental implementation of world-class problems in all fields such as physical engineering, biomedicine, energy materials, and artificial intelligence. This paper provides a unified underlying theoretical basis for the full series of application papers (controlled nuclear fusion, Alzheimer's disease, post-Moore chips, lithium batteries, etc.), and is a key practical achievement of the ontology of cognitive succession from explaining the world to transforming the world.
Mingxiang Liu (Mon,) studied this question.