May 8, 2020Open Access

Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

PICO estructurado

Do exosomes derived from hypoxia-preconditioned MSCs prevent doxorubicin-induced cardiac senescence in human iPSC-derived cardiomyocytes?

Población

Human-induced pluripotent stem cell-derived cardiomyocytes and human adipose-derived mesenchymal stem cells (MSCs) treated with doxorubicin (0.5 μM for 24 h) to model cardiac injury

Intervención

Exosomes derived from hypoxia-preconditioned MSCs (exosomeHypoxia)

Comparador

Exosomes derived from MSCs without any treatment (exosome) or untreated cardiomyocytes

Resultado

Doxorubicin-induced cellular senescence (measured by cell cycle distribution, p53 and p21 expression, and SA-β-gal staining)surrogate

Exosomes from hypoxia-preconditioned MSCs attenuate doxorubicin-induced cardiac senescence via the lncRNA-MALAT1/miR-92a-3p/ATG4a pathway, suggesting a potential therapeutic target for chemotherapy-induced cardiomyopathy.

Resumen

may serve as a potential therapeutic target against DIC.

Preguntar a la IA

Me gusta

Guardar

Ver artículo completo

Cite This Study

Xia et al. (Fri,) studied this question.

synapsesocial.com/papers/6a2a5075a94d6bc7baa23483 https://doi.org/https://doi.org/10.18632/aging.103136

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Preguntar a la IA

Me gusta

Guardar

Ver artículo completo