Due to the explosive rise of lanthanides and flavonoids in the biomedical and pharmaceutical industries, hybrid metal-organic materials and modified flavonoid compounds that can exert certain biological activities are on the rise. Lanthanides introduced in this study, i.e. Lanthanum, Neodymium and Europium, were selected to synthesize ternary compounds by reacting them with Chrysin, a flavonoid, and 1,10-phenanthroline, an aromatic chelator agent. Flavonoid-containing materials were synthesized from naringin and naringenin together with diamines through Schiff base condensation reactions. The antibacterial activity of those compounds was investigated using the disc diffusion method on Gram-negative Escherichia coli and Xanthomonas campestris and Gram-positive Staphylococcus aureus bacteria. The results for lanthanide metal-organic compounds showed low minimum inhibitory concentration (MIC) values, which indicated a significant inhibitory action against Escherichia coli. These compounds, however, showed little to no zone of inhibition against Staphylococcus aureus, indicating that their effectiveness against Gram-positive bacteria was limited. Flavonoid-containing compounds also showed high inhibitory action against Escherichia coli, but no activity in the Gram-negative Xanthomonas campestris strain and Gram-positive Staphylococcus aureus strain. The collective results demonstrate the selective antibacterial properties of the investigated compounds and underline the necessity for additional structural modifications to increase their selective efficacy against a wider variety of bacterial infections.
Nadim Al Lati (Thu,) studied this question.