Clonal expansion of CAR-T cells harboring lentivector integration in the PLAAT4 gene following anti-CD19 CAR T-cell therapy in a context of cutaneous T-cell lymphoma | Synapse
June 13, 2026Open Access
Clonal expansion of CAR-T cells harboring lentivector integration in the PLAAT4 gene following anti-CD19 CAR T-cell therapy in a context of cutaneous T-cell lymphoma
Puntos clave
This research investigates the clonal expansion of CAR-T cells with lentivector integration at the PLAAT4 gene following anti-CD19 CAR-T therapy in cutaneous T-cell lymphoma.
Examined CAR-T cells post-therapy for evidence of clonal expansion and lentivector integration.
Assessed integration specifically at the PLAAT4 gene within the context of cutaneous T-cell lymphoma.
Demonstrated significant clonal expansion of CAR-T cells post-therapy.
Lentivector integration was predominantly identified at the PLAAT4 gene, suggesting a functional genetic modification.