Frailty assessed by the Fried's Frailty Scale was associated with fewer days alive and out of hospital post-MI (P<0.001) and increased risk of death and reinfarction (HR 2.70; 95% CI 1.32-5.51).
Cohort (n=150)
Does frailty assessed by FFS or CFS predict days alive and out of hospital, mortality, and reinfarction in older patients after acute myocardial infarction?
Frailty assessment using either the Fried's Frailty Scale or Clinical Frailty Scale provides important prognostic information regarding days alive and out of hospital, mortality, and reinfarction in older adults following acute myocardial infarction.
valor p: p=<0.001 for FFS and 0.049 for CFS
We aimed to compare the prognostic value of two different measures, the Fried’s Frailty Scale (FFS) and the Clinical Frailty Scale (CFS), following myocardial infarction (MI). We included 150 patients ≥ 70 years admitted from AMI. Frailty was evaluated on the day before discharge. The primary endpoint was number of days alive and out of hospital (DAOH) during the first 800 days. Secondary endpoints were mortality and a composite of mortality and reinfarction. Frailty was diagnosed in 58% and 34% of patients using the FFS and CFS scales, respectively. During the first 800 days 34 deaths and 137 admissions occurred. The number of DAOH decreased significantly with increasing scores of both FFS (p < 0.001) and CFS (p = 0.049). In multivariate analysis, only the highest scores (FFS = 5, CFS ≥ 6) were independently associated with fewer DAOH. At a median follow-up of 946 days, frailty assessed both by FFS and CFS was independently associated with death and MI (HR = 2.70 95%CI = 1.32–5.51 p = 0.001; HR = 2.01 95%CI = 1.1–3.66 p = 0.023, respectively), whereas all-cause mortality was only associated with FFS (HR = 1.51 95%CI = 1.08–2.10 p = 0.015). Frailty by FFS or CFS is independently associated with shorter number DAOH post-MI. Likewise, frailty assessed by either scale is associated with a higher rate of death and reinfarction, whereas FFS outperforms CFS for mortality prediction.
García‐Blas et al. (Tue,) conducted a cohort in Acute Myocardial Infarction (n=150). Frailty assessed by Fried's Frailty Scale (FFS) and Clinical Frailty Scale (CFS) vs. Lower frailty scores was evaluated on Number of days alive and out of hospital (DAOH) during the first 800 days (p=<0.001 for FFS and 0.049 for CFS). Frailty assessed by the Fried's Frailty Scale was associated with fewer days alive and out of hospital post-MI (P<0.001) and increased risk of death and reinfarction (HR 2.70; 95% CI 1.32-5.51).