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TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease | Synapse

August 2, 2012Open Access

TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease

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Resumen

TDP-43 protein is the major component of the ubiquitin-positive inclusions in neurons and glia of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).11 TDP-43 pathology has also been detected in as many as 56% of patients with Alzheimer disease (AD

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Cite This Study

Rutherford et al. (Thu,) studied this question.

synapsesocial.com/papers/6a314f7d65e24aa33f6aab43 https://doi.org/https://doi.org/10.1212/wnl.0b013e318264e3ac

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-432007 · 373 citations
2Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis2006 · 6,628 citations
3Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity2009 · 617 citations
4<i>TMEM106B</i> regulates progranulin levels and the penetrance of FTLD in <i>GRN</i> mutation carriers2010 · 249 citations
5Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions2010 · 610 citations