Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition that causes permanent damage alveoli and makes it hard to breathe. Studies show that when the normal balance of alveolar epithelial cells is disrupted, it plays a key role in how COPD develops and gets worse over time. This imbalance involves several connected problems: AT2 progenitor cells don’t multiply and change into other cell types as well as they should, both AT1 and AT2 cells die off and age faster than normal, the body runs out of its stem cell supply, and the lungs can’t heal properly after injury. This review looks at how SIRT1, an enzyme that depends on NAD + , helps keep lung epithelial cells working properly by managing oxidative stress, cell aging, and the cell’s cleanup processes. We also examine how problems with SIRT1 contribute to COPD getting worse. Future research should focus on using multiomics techniques to identify different patient groups for personalized treatments, while also creating targeted drug delivery systems for more accurate COPD therapies.
Liang et al. (Mon,) studied this question.