The early COVID-19 pandemic was associated with a substantial increase in mortality for acute myocardial infarction compared to the pre-pandemic period (17.7% vs 5.2%, P<0.05).
Cross-Sectional (n=355)
No
Does the early COVID-19 pandemic affect hospital admissions, mortality, and clinical outcomes in patients with acute myocardial infarction?
The early COVID-19 pandemic was associated with a 50% reduction in AMI admissions but a significant increase in AMI mortality and worse cardiac outcomes, likely driven by delayed patient presentation.
Tasa de eventos absoluta: 17.7% vs 5.2%
valor p: p=< 0.05
AIMS: This study aimed to evaluate the impact of coronavirus disease 2019 (Covid-19) outbreak on admissions for acute myocardial infarction (AMI) and related mortality, severity of presentation, major cardiac complications and outcome in a tertiary-care university hospital in Berlin, Germany. METHODS AND RESULTS: In a single-centre cross-sectional observational study, we included 355 patients with AMI containing ST-elevation or non-ST-elevation myocardial infarction (STEMI or NSTEMI), admitted for emergency cardiac catheterization between January and April 2020 and the equivalent time in 2019. During the early phase of the Covid-19 pandemic (e-COV) in Berlin (March and April 2020), admissions for AMI halved compared with those in the pre-Covid-19 time (January and February 2020; pre-COV) and with those in the corresponding months in 2019. However, mortality for AMI increased substantially from 5.2% pre-COV to 17.7% (P 72 h +21% in STEMI, p = 0.04 and presentation > 72 h in NSTEMI +22%, p = 0.02). Door to balloon time was similar in STEMI patients, while time from first medical contact to revascularization was significantly delayed in NSTEMI patients (p = 0.02). Major cardiac complications after AMI occurred significantly more often, and cardiac recovery was worse in e-COV than in pre-COV, demonstrated by a significantly lower LVEF (39 ± 16 vs. 46 ± 16, p < 0.05) at hospital discharge and substantially higher NTproBNP levels. CONCLUSIONS: The Covid-19 outbreak affects hospital admissions for acute coronary syndromes. During the first phase of the pandemia, significantly less patients with AMI were admitted, but those admitted presented with a more severe phenotype and had a higher mortality, more complications, and a worse short-term outcome. Therefore, our data indicate that Covid-19 had relevant impact on non-infectious disease states, such as acute coronary syndromes.
Primeßnig et al. (Sun,) conducted a cross-sectional in Acute myocardial infarction (AMI) (n=355). Early phase of the COVID-19 pandemic (e-COV) vs. Pre-COVID-19 time (pre-COV) was evaluated on Mortality for AMI (p=< 0.05). The early COVID-19 pandemic was associated with a substantial increase in mortality for acute myocardial infarction compared to the pre-pandemic period (17.7% vs 5.2%, P<0.05).