An abluminal biodegradable polymer-coated sirolimus-eluting stent demonstrated significantly less fibrin deposition (0.10 vs 0.19 mm2, p=0.0004) and greater endothelial cell recovery at 7 days compared to a durable polymer-coated everolimus-eluting stent in a porcine model.
Does an abluminal biodegradable polymer-coated stent reduce early fibrin deposition and improve endothelialization compared to a durable polymer-coated stent in a porcine coronary model?
In a porcine model, abluminal biodegradable polymer-coated sirolimus-eluting stents demonstrated less early fibrin deposition and better endothelial cell recovery compared to durable polymer-coated everolimus-eluting stents.
Tasa de eventos absoluta: 0.1% vs 0.19%
valor p: p=0.0004
Current drug-eluting stents have abluminal polymer coating; however, thrombus formation in these compared with that in uniformly coated stents remains controversial. We evaluated thrombus formation and early endothelialization after using abluminal biodegradable polymer-coated sirolimus- (BP-SES), and everolimus-eluting stents (BP-EES) versus a durable polymer-coated everolimus-eluting stent (DP-EES) in an in vivo setting. BP-SES, BP-EES, and DP-EES (n = 6 each) were implanted in coronary arteries of 12 mini-pigs that were then sacrificed after 7 and 10 days. Stents were stained with hematoxylin and eosin, and a combined Verhoeff and Masson trichrome stain. Areas of fibrin deposition were digitally detected and measured with off-line morphometric software. Stents were investigated for re-endothelialization by transmission electron microscopy. At 7 days, histological analysis revealed the lowest area of fibrin deposition in BP-SES (BP-SES vs. BP-EES vs. DP-EES; 0.10 ± 0.06 mm2 vs. 0.15 ± 0.07 mm2 vs. 0.19 ± 0.06 mm2, p = 0.0004). At 10 days, the area of fibrin deposition was significantly greater in DP-EES (0.13 ± 0.04 mm2 vs. 0.14 ± 0.05 mm2 vs. 0.19 ± 0.08 mm2, p = 0.007). Endothelial cells in BP-SES demonstrated a significantly greater number of tight junctions than those in DP-EES according to by transmission electron microscopy for both days (p<0.05). Various parameters, including an inflammatory reaction and neointimal formation, were comparable among the groups at 7 and 10 days. An abluminal biodegradable polymer-coated SES showed the least fibrin deposition and greatest endothelial cell recovery at an early stage following implantation in the coronary arteries of mini-pigs.
Ijichi et al. (Thu,) conducted a other in Healthy porcine coronary artery model (n=14). Biodegradable polymer-coated sirolimus-eluting stent (BP-SES) vs. Durable polymer-coated everolimus-eluting stent (DP-EES) was evaluated on Area of fibrin deposition at 7 days (mm2) (p=0.0004). An abluminal biodegradable polymer-coated sirolimus-eluting stent demonstrated significantly less fibrin deposition (0.10 vs 0.19 mm2, p=0.0004) and greater endothelial cell recovery at 7 days compared to a durable polymer-coated everolimus-eluting stent in a porcine model.
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