Metabolic and bariatric surgery in severely obese adolescents significantly reduced the prevalence of having ≥3 cardiovascular disease risk factors from 33% at baseline to 5% at 3 years.
Cohort (n=242)
Sí
What are the predictors of change in cardiovascular disease risk factors 3 years after metabolic and bariatric surgery in severely obese adolescents?
In severely obese adolescents, metabolic and bariatric surgery improves cardiovascular risk factors at 3 years, with greater weight loss, younger age, and female sex predicting better resolution.
Tasa de eventos absoluta: 5% vs 33%
valor p: p=<0.001
BACKGROUND AND OBJECTIVES: Severely obese adolescents harbor numerous cardiovascular disease risk factors (CVD-RFs), which improve after metabolic and bariatric surgery (MBS). However, predictors of change in CVD-RFs among adolescents have not yet been reported. METHODS: The Teen-Longitudinal Assessment of Bariatric Surgery study (NCT00474318) prospectively collected anthropometric and health status data on 242 adolescents undergoing MBS at 5 centers. Predictors of change in CVD-RFs (blood pressure, lipids, glucose homeostasis, and inflammation) 3 years after Roux-en-Y gastric bypass and vertical sleeve gastrectomy were examined. RESULTS: = 14). Increasing weight loss was an independent predictor of normalization in dyslipidemia, elevated blood pressure (EBP), hyperinsulinemia, diabetes, and elevated high-sensitivity C-reactive protein. Older participants at time of surgery were less likely to resolve dyslipidemia compared with younger participants, whereas girls were more likely than boys to demonstrate improvements in EBP. Even those participants without frank dyslipidemia or EBP at baseline showed significant improvements in lipid and blood pressure values over time. CONCLUSIONS: Numerous CVD-RFs improve among adolescents undergoing MBS. Increased weight loss, female sex, and younger age predict a higher probability of resolution of specific CVD-RFs. The elucidation of predictors of change in CVD-RFs may lead to refinements in patient selection and optimal timing of adolescent bariatric surgery designed to improve clinical outcomes.
Michalsky et al. (Mon,) conducted a cohort in Severe obesity with comorbid disease (n=242). Metabolic and bariatric surgery vs. Baseline (pre-surgery) was evaluated on Presence of ≥3 cardiovascular disease risk factors (p=<0.001). Metabolic and bariatric surgery in severely obese adolescents significantly reduced the prevalence of having ≥3 cardiovascular disease risk factors from 33% at baseline to 5% at 3 years.